Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci
نویسندگان
چکیده
منابع مشابه
Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans.
Genome-wide association studies of colorectal cancer (CRC) in Europeans and Asians have identified 21 risk susceptibility regions [29 index single-nucleotide polymorphisms (SNPs)]. Characterizing these risk regions in diverse racial groups with different linkage disequilibrium (LD) structure can help localize causal variants. We examined associations between CRC and all 29 index SNPs in 6597 Af...
متن کاملGenome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
BACKGROUND We report a genome-wide association study (GWAS) of nicotine dependence defined on the basis of scores on the Fagerström Test for Nicotine Dependence in European-American (EA) and African-American (AA) populations. METHODS Our sample, from the one used in our previous GWAS, included only subjects who had smoked >100 cigarettes lifetime (2114 EA and 2602 AA subjects) and an addition...
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Sarcoidosis is a systemic inflammatory disease characterized by the formation of granulomas in affected organs. Genome-wide association studies (GWASs) of this disease have been conducted only in European population. We present the first sarcoidosis GWAS in African Americans (AAs, 818 cases and 1,088 related controls) followed by replication in independent sets of AAs (455 cases and 557 control...
متن کاملGenome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.
Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorders. This genome-wide association study (GWAS) was designed to shed light on the genetic basis of fasting insulin (FI) and IR in 927 non-diabetic African Americans. 5 396 838 single-nucleotide polymorphisms (SNPs) were tested for associations with FI or IR with adjustments for age, sex, body mass ind...
متن کاملEvaluation of genome-wide association study-identified type 2 diabetes loci in African Americans.
Type 2 diabetes (T2D) is up to twice as prevalent among African Americans as Caucasians. Recent genome-wide association studies (GWAS) have identified multiple common genetic risk variants for T2D; however, none of these studies were conducted exclusively among subjects of African ancestry. Investigating these known loci in other populations would be an expedient way to evaluate the generalizab...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2013
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2013.145